The Journal of Toxicological Sciences

Vol.46, No.12, 2021

Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species

Makiko Kuwagata, Takuro Hasegawa, Hiromasa Takashima, Makiko Shimizu, Satoshi Kitajima, Hiroshi Yamazaki

J. Toxicol. Sci., Vol.46, No.12, 553-560, 2021

Corneal lesions related to an anesthetic mixture of medetomidine, midazolam, and butorphanol treatment in rats

Kyohei Kamio, Junya Morita, Yutaka Nakanishi, Minoru Sasaki, Masaki Wakamatsu

J. Toxicol. Sci., Vol.46, No.12, 561-568, 2021

Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats

Susumu Kodama, Nao Yoshii, Akihiro Ota, Jun-ichi Takeshita, Kouichi Yoshinari, Atsushi Ono

J. Toxicol. Sci., Vol.46, No.12, 569-587, 2021

Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus

Soon Hui Teoh, Katsuhiro Miyajima, Yuichi Shinozaki, Masami Shinohara, Keiichi Ohata, François Briand, Rika Morimoto, Yuka Nakamura, Kinuko Uno, Noriko Kemuriyama, Dai Nakae, Takeshi Ohta, Tatsuya Maekawa

J. Toxicol. Sci., Vol.46, No.12, 589-599, 2021

Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

Kohei Matsunaga, Jun Abe, Keiko Ogata, Satoki Fukunaga, Sachiko Kitamoto

J. Toxicol. Sci., Vol.46, No.12, 601-609, 2021

Detection of double-stranded DNA breaks and apoptosis induced by bleomycin in mouse intestine

Togo Ikuta, Aki Koike, Manabu Koike

J. Toxicol. Sci., Vol.46, No.12, 611-618, 2021

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This journal is supported by
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Title: The Journal of Toxicological Sciences

Abbreviation: J. Toxicol. Sci.

Publisher: The Japanese Society of Toxicology

Editor-in-Chief: Toshiyuki Kaji

Frequency of Publication: monthly

Editorial Office:
Faculty of Pharmaceutical Sciences
Tokyo University of Science
2641 Yamazaki, Noda 278-8510 JAPAN

E-mail: jts-ed@jtoxsci.org

ISSN	Online ISSN: 1880-3989
	Print ISSN: 0388-1350