Top 10 papers by download from our web site

February 2010

1．104 times
History of dose response
William J. Waddell
J. Toxicol. Sci., 35: 1-8 (2010).

2．100 times
Study on penetration of titanium dioxide (TiO₂) nanoparticles into intact and damaged skin in vitro
Mika Senzui, Toshiaki Tamura, Keiko Miura, Yoshiaki Ikarashi, Yoshiteru Watanabe and Makiko Fujii
J. Toxicol. Sci., 35: 107-113 (2010).

3．89 times
Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
Atsuya Takagi, Akihiko Hirose, Tetsuji Nishimura, Nobutaka Fukumori, Akio Ogata, Norio Ohashi, Satoshi Kitajima and Jun Kanno
J. Toxicol. Sci., 33: 105-116 (2008).

4．88 times
The predictivity of preliminary embryo-fetal development (EFD) studies: results of a retrospective survey in Japanese pharmaceutical companies
Noriko Okahashi, Takashi Ikeda, Shuichi Kai, Shinichi Komatsu, Hajime Matsui, Yasuhiro Yamashita, Keiji Yamamoto and Fumio Sagami
J. Toxicol. Sci., 35: 21-31 (2010).

5．78 times
COMMON PATHOGENIC MECHANISM IN DEVELOPMENT PROGRESSION OF LIVER INJURY CAUSED BY NON-ALCOHOLIC OR ALCOHOLIC STEATOHEPATITIS
Kiyoshi NAGATA, Hiroyuki SUZUKI and Shuhei SAKAGUCHI
J. Toxicol. Sci., 32: 453-468 (2007).

6．73 times
Cytotoxicity of nanoparticles independent from oxidative stress
Eleonore Fröhlich, Claudia Samberger, Tatjana Kueznik, Markus Absenger, Eva Roblegg, Andreas Zimmer and Thomas R. Pieber
J. Toxicol. Sci., 34: 363-375 (2009).

7．69 times
Extracellular signal-regulated kinase (ERK) inhibition attenuates cigarette smoke extract (CSE) induced-death inducing signaling complex (DISC) formation in human lung fibroblasts (MRC-5) cells
Jeong-Woong Park, Jin Young Yoon, Yu Jin Kim, Sun Young Kyung, Sang Pyo Lee, Sung Hwan Jeong and Chanil Moon
J. Toxicol. Sci., 35: 33-39 (2010).

8．68 times
Low-dose effects of bisphenol A: a serious threat to human health?
Jun Sekizawa
J. Toxicol. Sci., 33: 389-403 (2008).

9．59 times
Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1
Daigo Sumi, Yumiko Numasawa, Akiko Endo, Noriko Iwamoto and Yoshito Kumagai
J. Toxicol. Sci., 34: 627-635 (2009).

9．59 times
Essentials for starting a pediatric clinical study (1): Pharmacokinetics in children
Tsuyoshi Yokoi
J. Toxicol. Sci., 34: SP307-SP312 (2009).

The Journal of Toxicological Sciences (J. Toxicol. Sci.) published by The Japanese Society of Toxicology