Top 10 papers by download from our web site

December 2013

1．69 times
Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells
Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masanobu Uchiyama, Masahiko Satoh
J. Toxicol. Sci., 38: 815-820 (2013).

2．67 times
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan
Chihiro Tamaki, Takashi Nagayama, Masamichi Hashiba, Masato Fujiyoshi, Masanori Hizue, Hiroshi Kodaira, Minoru Nishida, Kazuhiko Suzuki, Yoshiharu Takashima, Yamato Ogino, Daisaku Yasugi, Yasuo Yoneta, Shigeru Hisada, Takako Ohkura, Kazuichi Nakamura
J. Toxicol. Sci., 38: 581-598 (2013).

3．57 times
Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells
Seung-Hee Chang, Hong Ju Lee, Bitna Kang, Kyeong-Nam Yu, Arash Minai-Tehrani, Somin Lee, Seung U. Kim, Myung-Haing Cho
J. Toxicol. Sci., 38: 823-831 (2013).

4．55 times
Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium
Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Masahiko Satoh
J. Toxicol. Sci., 38: 959-962 (2013).

5．53 times
QUANTITATIVE MEASUREMENT OF SPLICED XBP1 mRNA AS AN INDICATOR OF ENDOPLASMIC RETICULUM STRESS
Morihiko HIROTA, Masato KITAGAKI, Hiroshi ITAGAKI, Setsuya AIBA
J. Toxicol. Sci., 31: 149-156 (2006).

6．51 times
Cytotoxicity of nanoparticles independent from oxidative stress
Eleonore Fröhlich, Claudia Samberger, Tatjana Kueznik, Markus Absenger, Eva Roblegg, Andreas Zimmer, Thomas R. Pieber
J. Toxicol. Sci., 34: P363-375 (2009).

7．50 times
Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury
Takashi Hirooka, Chika Yamamoto, Akira Yasutake, Komyo Eto, Toshiyuki Kaji
J. Toxicol. Sci., 38: 837-845 (2013).

8．47 times
Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells
Yasuhiro Shinkai, Ichiro Yamanaka, Ho Huynh Thuy Duong, Nguyen Thi Quynh, Yasunori Kanaho, Yoshito Kumagai
J. Toxicol. Sci., 38: 875-878 (2013).

9．44 times
Mechanisms of cadmium-induced chronotoxicity in mice
Nobuhiko Miura, Atsushige Ashimori, Asuka Takeuchi, Katsumi Ohtani, Naoko Takada, Yukie Yanagiba, Masaharu Mita, Masako Togawa, Tatsuya Hasegawa
J. Toxicol. Sci., 38: 947-957 (2013).

10．38 times
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes
Adarsh Gandhi, Tao Guo, Romi Ghose
J. Toxicol. Sci., 35: 163-173 (2010).

10．38 times
Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold
Kazuaki Nakamura, Natsuko Kato, Kazuko Aizawa, Reiko Mizutani, Junji Yamauchi, Akito Tanoue
J. Toxicol. Sci., 36: 625-633 (2011).

The Journal of Toxicological Sciences (J. Toxicol. Sci.) published by The Japanese Society of Toxicology