Top 10 papers by download from our web site

July 2015

1．106 times
New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP) activates central nervous system via dopaminergic neuron
Asuka Kaizaki, Sachiko Tanaka, Satoshi Numazawa
J. Toxicol. Sci., 39: 1-6 (2014).

2．81 times
Cell-type-specific and differentiation-status-dependent variations in cytotoxicity of tributyltin in cultured rat cerebral neurons and astrocytes
Koshi Oyanagi, Tomoko Tashiro, Takayuki Negishi
J. Toxicol. Sci., 40: 459-468 (2015).

3．75 times
Cytotoxicity of proparacaine to human corneal endothelial cells in vitro
Qian Wen, Tingjun Fan, Suran Bai, Yunlong Sui
J. Toxicol. Sci., 40: 427-436 (2015).

4．71 times
Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells
Tomofumi Fujino, Akiko Maruko-Ohtake, Yosuke Ohtake, Tomonori Kobayashi, Ken Ando, Airi Takeuchi, Yasuhito Ohkubo, Makio Hayakawa
J. Toxicol. Sci., 40: 501-508 (2015).

5．67 times
Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice
Terumasa Hashimoto, Yang-Il Fang, Hisayuki Ohata, Kazuo Honda
J. Toxicol. Sci., 40: 451-457 (2015).

6．64 times
Hepatic glutathione contributes to attenuation of thioacetamide-induced hepatic necrosis due to suppression of oxidative stress in diet-induced obese mice
Makoto Shirai, Miho Matsuoka, Toshihiko Makino, Kiyonori Kai, Munehiro Teranishi, Wataru Takasaki
J. Toxicol. Sci., 40: 509-521 (2015).

7．61 times
QUANTITATIVE MEASUREMENT OF SPLICED XBP1 mRNA AS AN INDICATOR OF ENDOPLASMIC RETICULUM STRESS
Morihiko HIROTA, Masato KITAGAKI, Hiroshi ITAGAKI, Setsuya AIBA
J. Toxicol. Sci., 31: 149-156 (2006).

7．61 times
General considerations in ocular toxicity risk assessment from the toxicologists' viewpoints
Hiroshi Onodera, Shoji Sasaki, Seiji Otake, Masayuki Tomohiro, Kazumoto Shibuya, Mamoru Nomura
J. Toxicol. Sci., 40: 295-307 (2015).

9．60 times
Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra
Bo Zhang, Kun Ma, Baixiang Li
J. Toxicol. Sci., 40: 437-450 (2015).

10．57 times
Hepatotoxicants induce cytokine imbalance in response to innate immune system
Shima Goto, Jiro Deguchi, Naoki Nishio, Naruaki Nomura, Hitoshi Funabashi
J. Toxicol. Sci., 40: 389-404 (2015).

The Journal of Toxicological Sciences (J. Toxicol. Sci.) published by The Japanese Society of Toxicology