Top 10 papers by download from our web site

March 2020

1. 69 times
Silica nanoparticles enhance germ cell apoptosis by inducing reactive oxygen species (ROS) formation in Caenorhabditis elegans
Fangfang Zhang, Xinyue You, Tengteng Zhu, Sumeng Gao, Yu Wang, Ruoyang Wang, Herbert Yu, Biyun Qian
J. Toxicol. Sci., 45: 117-129 (2020)

2. 60 times
Development of pain therapies targeting nerve growth factor signal transduction and the strategies used to resolve safety issues
Patrice Bélanger, Christine R. West, Mark T. Brown
J. Toxicol. Sci., 43: 1-10 (2018)

3. 44 times
Safety biomarker applications in drug development
Shelli Schomaker, Shashi Ramaiah, Nasir Khan, John Burkhardt
J. Toxicol. Sci., 44: 225-235 (2019)

4. 43 times
Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries
Eita Sasaki, Tsuyoshi Yokoi
J. Toxicol. Sci., 43: 75-87 (2018)

4. 43 times
Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan)
Mariko Sugiyama, Masaharu Akita, Nathalie Alépée, Miyuki Fujishiro, Shigenobu Hagino, Yuki Handa, Hidefumi Ikeda, Noriyasu Imai, Setsuko Jitsukawa, Masakazu Katoh, Koji Kurihara, Daiki Kyotani, Shigeyuki Nomura, Yuko Okamoto, Hidenobu Okumura, Takashi Omori, Kenji Sugibayashi, Hiroaki Todo, Akemi Toyoda, Yasuo Ohno
J. Toxicol. Sci., 43: 751-768 (2018)

4. 43 times
Immunosuppressive drugs to reduce the mortality rate in patients with moderate to severe paraquat poisoning: A Meta-analysis
Yan-Xia Gao, Yi-Bo Wang, You-Dong Wan, Tong-Wen Sun, Yi Li, Lin-Lin Hou, Pei Sun, Ding Yuan, Guo-Yu Duan, Chang-Hua Sun, Lu Che, Yan Zhang
J. Toxicol. Sci., 45: 163-175 (2020)

4. 43 times
Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease
Masaaki Miyata, Akihiro Funaki, Chiaki Fukuhara, Yukino Sumiya, Yoshimasa Sugiura
J. Toxicol. Sci., 45: 87-94 (2020)

8. 39 times
Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR
Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
J. Toxicol. Sci., 43: 443-450 (2018)

8. 39 times
In silico systems for predicting chemical-induced side effects using known and potential chemical protein interactions, enabling mechanism estimation
Yuto Amano, Hiroshi Honda, Ryusuke Sawada, Yuko Nukada, Masayuki Yamane, Naohiro Ikeda, Osamu Morita, Yoshihiro Yamanishi
J. Toxicol. Sci., 45: 137-149 (2020)

10. 38 times
Avian eggshell thinning caused by transovarian exposure to o,p′-DDT: changes in histology and calcium-binding protein production in the oviduct uterus
Ryo Kamata, Fujio Shiraishi, Kazuichi Nakamura
J. Toxicol. Sci., 45: 131-136 (2020)

The Journal of Toxicological Sciences (J. Toxicol. Sci.) published by The Japanese Society of Toxicology