Top 10 papers by download from our web site

April 2020

1. 131 times
4-Methylthio-3-butenyl isothiocyanate (MTBITC) induced apoptotic cell death and G2/M cell cycle arrest via ROS production in human esophageal epithelial cancer cells
Tadashi Hirata, Young-Man Cho, Isamu Suzuki, Takeshi Toyoda, Jun-ichi Akagi, Yasushi Nakamura, Satoshi Numazawa, Kumiko Ogawa
J. Toxicol. Sci., 44: 73-81 (2019)

2. 97 times
A novel screening test to predict the developmental toxicity of drugs using human induced pluripotent stem cells
Nobuo Aikawa
J. Toxicol. Sci., 45: 187-199 (2020)

3. 72 times
Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin
Mei Tsuchida, Takumi Yokosawa, Takuya Noguchi, Tatsuya Shimada, Mayuka Yamada, Yuto Sekiguchi, Yusuke Hirata, Atsushi Matsuzawa
J. Toxicol. Sci., 45: 219-226 (2020)

4. 66 times
Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR
Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
J. Toxicol. Sci., 43: 443-450 (2018)

5. 63 times
Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model
Takehito Isobe, Masaki Honda, Ryuichi Komatsu, Mitsuyasu Tabo
J. Toxicol. Sci., 43: 493-506 (2018)

5. 63 times
Drug-induced lenticular opacity and accumulation of cholesterol-related substances in the lens cortex of dogs
Hiroshi Iwasaki, Masaki Wakamatsu, Kazunari Sugihara, Kyohei Kamio, Satoshi Tsuji, Junya Morita, Yasuhiro Kurihara, Tomoko Izumi, Tomohiro Nishimoto, Kohnosuke Kinoshita, Yutaka Nakanishi, Minoru Sasaki
J. Toxicol. Sci., 45: 201-218 (2020)

7. 60 times
Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan)
Mariko Sugiyama, Masaharu Akita, Nathalie Alépée, Miyuki Fujishiro, Shigenobu Hagino, Yuki Handa, Hidefumi Ikeda, Noriyasu Imai, Setsuko Jitsukawa, Masakazu Katoh, Koji Kurihara, Daiki Kyotani, Shigeyuki Nomura, Yuko Okamoto, Hidenobu Okumura, Takashi Omori, Kenji Sugibayashi, Hiroaki Todo, Akemi Toyoda, Yasuo Ohno
J. Toxicol. Sci., 43: 751-768 (2018)

8. 59 times
Safety biomarker applications in drug development
Shelli Schomaker, Shashi Ramaiah, Nasir Khan, John Burkhardt
J. Toxicol. Sci., 44: 225-235 (2018)

9. 57 times
5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells
Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda
J. Toxicol. Sci., 43: 727-734 (2018)

10. 51 times
Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells
Tsutomu Takahashi, Tsuyoshi Nakano, Go Katoh, Yo Shinoda, Chika Yamamoto, Eiko Yoshida, Toshiyuki Kaji, Yasuyuki Fujiwara
J. Toxicol. Sci., 45: 237-243 (2020)

The Journal of Toxicological Sciences (J. Toxicol. Sci.) published by The Japanese Society of Toxicology