30th, 2024

Paper:

Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compounds

Author:

Takashi Kitaguchi, Shinichiro Horiuchi, Yukie Kuroda, Katsutoshi Ohno, Kazuhiro Kobayashi, Mitsuru Tanaka, Seiichi Ishida

Paper:

Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study

Author:

Masao Togao, Takashi Kurakawa, Shinnosuke Tajima, Gaku Wagai, Yuki Ohta-Takada, Jun Otsuka, Akinobu Kurita, Koji Kawakami

Paper:

Preclinical in vitro evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody

Author:

Yoshika Iwata, Hitoshi Katada, Momoko Okuda, Yoshiaki Doi, Tim Jang Ching, Asako Harada, Akira Takeiri, Masaki Honda, Masayuki Mishima

Paper:

Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7

Author:

Motomu Shimizu, Motoki Hojo, Kiyomi Ikushima, Yukio Yamamoto, Ai Maeno, Yoshimitsu Sakamoto, Naozumi Ishimaru, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose, Jin Suzuki, Akiko Inomata, Dai Nakae

29th, 2023

Paper:

A physiologically based kinetic modeling of ethyl tert-butyl ether in humans–An illustrative application of quantitative structure-property relationship and Monte Carlo simulation

Author:

Saori Watanabe-Matsumoto, Kikuo Yoshida, Yuriko Meiseki,Seiichi Ishida, Akihiko Hirose, Takashi Yamada

Paper:

Fetal loss due to Th1-skewed Th1/Th2 balance with increase (not decrease) of regulatory T cells in abortion-prone mouse model

Author:

Miho Sakakibara, Yosuke Maeda, Kazuichi Nakamura

Paper:

CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis

Author:

Qiyue Zhang, Shiori Taniguchi, Kanako So, Masahiro Tsuda, Yuriko Higuchi, Mitsuru Hashida, Fumiyoshi Yamashita

Paper:

Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicit

Author:

Tomomi Yoda, Tomoaki Tochitani, Toru Usui, Mami Kouchi, Hiroshi Inada, Takuomi Hosaka, Yuichiro Kanno, Izuru Miyawaki, Kouichi Yoshinari

28th, 2022

Paper:

Development of a new in vitro assay system for evaluating the effects of chemicals on DNA methylation

Author:

Maky Ideta-Otsuka, Misato Miyai, Naoki Yamamoto, Ayaka Tsuchimoto, Hideki Tamura, Kentaro Tanemura, Makoto Shibutani, Katsuhide Igarashi

Paper:

Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury

Author:

Yuki Shimizu, Takamitsu Sasaki, Eri Yonekawa, Hirokazu Yamazaki, Rui Ogura, Michiko Watanabe, Takuomi Hosaka, Ryota Shizu, Jun-ichi Takeshita, Kouichi Yoshinari

Paper:

Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing

Author:

Kayoko Tsuji, Shigeru Yamada, Kazuya Hirai, Hiroshi Asakura, Yasunari Kanda

27th, 2021

Paper:

Adjustment of a no expected sensitization induction level derived from Bayesian network integrated testing strategy for skin sensitization risk assessment

Author:

Yuki Otsubo, Taku Nishijo, Hideyuki Mizumachi, Kazutoshi Saito, Masaaki Miyazawa, Hitoshi Sakaguchi

Paper:

Integration of read-across and artificial neural network-based QSAR models for predicting systemic toxicity: A case study for valproic acid

Author:

Tomoka Hisaki, Maki Aiba née Kaneko, Morihiko Hirota, Masato Matsuoka, Hirokazu Kouzuki

Paper:

In silico systems for predicting chemical-induced side effects using known and potential chemical protein interactions, enabling mechanism estimation

Author:

Yuto Amano, Hiroshi Honda, Ryusuke Sawada, Yuko Nukada, Masayuki Yamane, Naohiro Ikeda, Osamu Morita, Yoshihiro Yamanishi

26th, 2020

Paper:

Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells

Author:

Yo Shinoda, Shunsuke Ehara, Satoshi Tatsumi, Eiko Yoshida, Tsutomu Takahashi, Komyo Eto, Toshiyuki Kaji, Yasuyuki Fujiwara

Paper:

Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events

Author:

Yusuke Yamamoto, Masaharu Fujita, Sayaka Wanibuchi, Ayako Sato, Miyuki Akimoto, Yasuhiro Katsuoka, Atsushi Ono, Toshihiko Kasahara

Paper:

Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells

Author:

Tatsuya Ikuno, Shunsuke Ito, Tomoaki Inoue

Paper:

Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling

Author:

Takehito Isobe, Masaki Honda, Ryuichi Komatsu, Mitsuyasu Tabo

25th, 2019

Paper:

Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR

Author:

Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari

Paper:

Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model

Author:

Takehito Isobe, Masaki Honda, Ryuichi Komatsu, Mitsuyasu Tabo

Paper:

5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells

Author:

Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda

Paper:

Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan)

Author:

Mariko Sugiyama, Masaharu Akita, Nathalie Alépée, Miyuki Fujishiro, Shigenobu Hagino, Yuki Handa, Hidefumi Ikeda, Noriyasu Imai, Setsuko Jitsukawa, Masakazu Katoh, Koji Kurihara, Daiki Kyotani, Shigeyuki Nomura, Yuko Okamoto, Hidenobu Okumura, Takashi Omori, Kenji Sugibayashi, Hiroaki Todo, Akemi Toyoda, Yasuo Ohno

24th, 2018

Paper:

Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance

Author:

Hiroko Izumi-Nakaseko, Yuji Nakamura, Takeshi Wada, Kentaro Ando, Yasunari Kanda, Yuko Sekino and Atsushi Sugiyama

Paper:

Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells

Author:

Naoya Hirata, Shigeru Yamada, Yuko Sekino and Yasunari Kanda

Paper:

Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics

Author:

Taisuke Kawamoto, Yuichi Ito, Osamu Morita and Hiroshi Honda

23rd, 2017

Paper:

Tributyltin induces G2/M cell cycle arrest via NAD⁺-dependent isocitrate dehydrogenase in human embryonic carcinoma cells

Author:

Miki Asanagi, Shigeru Yamada, Naoya Hirata, Hiroshi Itagaki, Yaichiro Kotake, Yuko Sekino and Yasunari Kanda

Paper:

Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets

Author:

Masayuki Kanki, Min Gi, Masaki Fujioka and Hideki Wanibuchi

Paper:

Demethylation of methylmercury and the enhanced production of formaldehyde in mouse liver

Author:

Takuya Uchikawa, Toshihiro Kanno, Isao Maruyama, Nobuko Mori, Akira Yasutake, Yuji Ishii and Hideyuki Yamada

Paper:

Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?

Author:

Yoshika Iwata, Asako Harada, Toshiko Hara, Chiyomi Kubo, Tomoaki Inoue, Mitsuyasu Tabo, Corinne Ploix, Tobias Manigold, Heather Hinton and Masayuki Mishima

22nd, 2016

Paper:

Prenatal diesel exhaust exposure disrupts the DNA methylation profile in the brain of mouse offspring

Author:

Ken Tachibana, Kohei Takayanagi, Ayame Akimoto, Kouji Ueda, Yusuke Shinkai, Masakazu Umezawa, Ken Takeda

Paper:

In silico risk assessment for skin sensitization using artificial neural network analysis

Author:

Kyoko Tsujita-Inoue, Tomomi Atobe, Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki

Paper:

Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogenesis in rats

Author:

Masayuki Kimura, Sayaka Mizukami, Yousuke Watanabe, Yasuko Hasegawa-Baba, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutani

Paper:

Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells

Author:

Yumi Abiko, Alvaro Puga, Yoshito Kumagai

21st, 2015

Paper:

An RNA synthesis inhibition assay for detecting toxic substances using click chemistry:

Author:

Yukiko Kametani, Shigenori Iwai and Isao Kuraoka

Paper:

Improvement of the evaluation method for teratogenicity using zebrafish embryos:

Author:

Akihito Yamashita, Hiroshi Inada, Kazuhiro Chihara, Toru Yamada, Jiro Deguchi and Hitoshi Funabashi

Paper:

FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation:

Author:

Ke Du, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma and Gi-Wook Hwang

20th, 2014

Paper:

Simulation of acute reference dose (ARfD) settings for pesticides in Japan:

Author:

Midori Yoshida, Daisetsu Suzuki, Kiyoshi Matsumoto, Mariko Shirota, Kaoru Inoue, Miwa Takahashi, Takeshi Morita and Atsushi Ono

Paper:

A convenient method to assess chemical modification of protein thiols by electrophilic metals:

Author:

Takashi Toyama, Yasuhiro Shinkai, Toshiyuki Kaji and Yoshito Kumagai

Paper:

Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death:

Author:

Keishi Ishida, Yaichiro Kotake, Masatsugu Miyara, Kaori Aoki, Seigo Sanoh, Yasunari Kanda and Shigeru Ohta

Paper:

Mechanisms of cadmium-induced chronotoxicity in mice:

Author:

Nobuhiko Miura, Atsushige Ashimori, Asuka Takeuchi, Katsumi Ohtani, Naoko Takada, Yukie Yanagiba, Masaharu Mita, Masako Togawa and Tatsuya Hasegawa

19th, 2013

Paper:

Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence:

Author:

Katsuhide Igarashi, Satoshi Kitajima, Ken-ichi Aisaki, Kentaro Tanemura, Yuhji Taquahashi, Noriko Moriyama, Eriko Ikeno, Nae Matsuda, Bruce Blumberg and Jun Kanno

Paper:

Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice:

Author:

Shingo Arakawa, Takanori Maejima, Kazunori Fujimoto, Ryo Atsumi and Yasushi Yamazoe

Paper:

A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways:

Author:

Reiko Hirose, Takashi Miura, Ryo Sha, Yasuhiro Shinkai, Toshiko Tanaka-Kagawa and Yoshito Kumagai

Paper:

Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats:

Author:

Eriko Taniai, Atsunori Yafune, Hitomi Hayashi, Megu Itahashi, Yukiko Hara-Kudo, Kazuhiko Suzuki, Kunitoshi Mitsumori and Makoto Shibutani

18th, 2012

Paper:

Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo.:

Author:

Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa and Yoshiyuki Seko

Paper:

Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans – toxicological implications:

Author:

Hidetoshi Shindoh, Kohnosuke Nakano and Takemi Yoshida

Paper:

Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats.:

Author:

Akio Kobayashi, Hideaki Yokoyama, Jiro Kataoka, Tomio Ishida, Hideyuki Kuno, Shoichiro Sugai, and Kayoko Shimoi

Paper:

Analysis of altered gene expression specific to embryotoxic chemical treatment during embryonic stem cell differentiation into myocardiac and neural cells.:

Author:

Noriyuki Suzuki, Satoshi Ando, Kayo Sumida and Koichi Saito

17th, 2011

Paper:

Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity:

Author:

Akiko Honda, Hiroaki Komuro, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Hisamitsu Nagase, Isao Hozumi, Takashi Inuzuka, Hideaki Hara, Yasuyuki Fujiwara and Masahiko Satoh

Paper:

Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis:

Author:

Yuki Matsumoto, Takumi Ishida, Tomoki Takeda, Takayuki Koga, Misaki Fujii, Yuji Ishii, Yoshinori Fujimura, Daisuke Miura, Hiroyuki Wariishi and Hideyuki Yamada

Paper:

Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection:

Author:

Naoteru Koseki, Jiro Deguchi, Toru Yamada, Hitoshi Funabashi and Takaki Seki

Paper:

1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation:

Author:

Daigo Sumi, Masako Akimori, Ken-ichiro Inoue, Hirohisa Takano and Yoshito Kumagai

16th, 2010

Paper:

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy:

Author:

Mitsuhiro Hirode, Ko Omura, Naoki Kiyosawa, Takeki Uehara, Toshinobu Shimuzu, Atsushi Ono, Toshikazu Miyagishima, Taku Nagao, Yasuo Ohno and Tetsuro Urushidani

Paper:

Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats: implication of hormesis-like effects:

Author:

Yasufumi Shutoh, Makio Takeda, Ryoichi Ohtsuka, Atsuko Haishima, Satoru Yamaguchi, Hideaki Fujie, Yutaka Komatsu, Keizo Maita and Takanori Harada

Paper:

Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1:

Author:

Daigo Sumi, Yumiko Numasawa, Akiko Endo, Noriko Iwamoto and Yoshito Kumagai

Paper:

Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs:

Author:

Toshihiko Makino, Junzo Kinoshita, Shingo Arakawa, Kazumi Ito, Yosuke Ando, Takashi Yamoto, Munehiro Teranishi, Atsushi Sanbuissho and Hiroyuki Nakayama

15th, 2009

Paper:

Role of TNF-α and extracellular ATP in THP-1 cell activation following allergen exposure:

Author:

Masaaki Miyazawa, Yuichi Ito, Nanae Kosaka, Yuko Nukada, Hitoshi Sakaguchi, Hiroyuki Suzuki and Naohiro Nishiyama

Paper:

Prevention of incipient diabetic cardiomyopathy by high-dose thiamine:

Author:

Yuka Kohda, Hisashi Shirakawa, Kazuhiko Yamane, Kaoru Otsuka, Tatsuji Kono, Fumio Terasaki and Takao Tanaka

Paper:

Protective role of metallothionein in bone marrow injury caused by X-irradiation:

Author:

Kiyoshi Shibuya, Junko S. Suzuki, Hideaki Kito, Akira Naganuma, Chiharu Tohyama and Masahiko Satoh

Paper:

Decrease in protein binding and its effect on toxicokinetics (TK) / toxicodynamics (TD) of diclofenac and propranolol in pregnant rats:

Author:

Hiroaki Miida, Yumiko Noritake, Hitomi Shimoda, Kumi Honda, Toshiki Matsuoka, Ken Sakurai, Makoto Shirai, Sunao Manabe, Wataru Takasaki and Koichi Ueno

14th, 2008

Paper:

OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (II); A CROSS-LABORATORY GENE EXPRESSION ANALYSIS:

Author:

Kayo SUMIDA, Koichi SAITO, Kenji OEDA, Masanori OTSUKA, Kazunari TSUJIMURA, Hideki MIYAURA, Masaru SEKIJIMA, Koji NAKAYAMA, Yukiko KAWANO, Yuki KAWAKAMI, Makoto ASAMOTO and Tomoyuki SHIRAI

Paper:

EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES - EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE:

Author:

Toshinori YAMAMOTO, Kaori TOMIZAWA, Masaaki FUJIKAWA, Yasushi SATO, Hiroshi YAMADA and Ikuo HORII

Paper:

CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE - REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION -:

Author:

Tamio FUKUSHIMA, Yoshimasa HAMADA, Hiroshi YAMADA and Ikuo HORII

13th, 2007

Paper:

INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER: TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS:

Author:

Toshinori YAMAMOTO, Rie KIKKAWA, Hiroshi YAMADA and Ikuo HORII

Paper:

INVOLVEMENT OF RAF-1/MEK/ERK1/2 SIGNALING PATHWAY IN ZINC-INDUCED INJURY IN RAT RENAL CORTICAL SLICES:

Author:

Yuka KOHDA, Yoshiko MATSUNAGA, Ryugo SHIOTA, Tomohiko SATOH, Yuko KISHI, Yoshiko KAWAI and Munekazu GEMBA

12th, 2006

Paper:

ROLES OF μ-OPIOID RECEPTORS IN DEVELOPMENT OF TOLERANCE TO DIISOPROPYLFLUOROPHOSPHATE (DFP):

Author:

Lu-Tai TIEN, Lir-Wan FAN, Tangeng MA, Horace H. LOH and Ing Kang HO

Paper:

INHIBITION OF NF-κB ACTIVATION DURING ISCHEMIA REDUCES HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS:

Author:

Nobuaki MATSUI, Kazumi KASAJIMA, Masazumi HADA, Tomomi NAGATA, Nobuko SENGA, Yumiko YASUI, Nobuyuki FUKUISHI and Masaaki AKAGI

Paper:

PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS:

Author:

Toshinori YAMAMOTO, Tamio FUKUSHIMA, Rie KIKKAWA, Hiroshi YAMADA and Ikuo HORII

11th, 2005

Paper:

AUTOMATED MEASUREMENT OF FREEZING TIME TO CONTEXTUAL AND AUDITORY CUES IN FEAR CONDITIONING AS A SIMPLE　SCREENING METHOD TO ASSESS LEARNING AND MEMORY ABILITIES IN RATS.:

Author:

Hiroaki TAKAHASHI

Paper:

SUBCELLULAR DISTRIBUTION OF DI-(2-ETHYLHEXYL) PHTHALATE IN RAT TESTIS.:

Author:

Hiroshi ONO, Yoshiaki SAITO, Kiyoshi IMAI and Masanobu KATO

10th, 2004

Paper:

BIOCHEMICAL AND MICROARRAY ANALYSES OF BUPIVACAINE-INDUCED APOPTOSIS.:

Author:

Akira UNAMI, Yasuo SHINOHARA, Tomokazu ICHIKAWA and Yoshinobu BABA

Paper:

DIFFERENTIAL MODULATION OF MUSCARINIC RECEPTORS IN THE RAT BRAIN BY REPEATED EXPOSURE TO METHYL PARATHION.:

Author:

SUN Tingting, MA Tangeng, HO Ing K.

9th, 2003

Paper:

ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE- AND ETHINYLESTRADIOL-TREATED RATS.:

Author:

Chiaki KATOH, Satoshi KITAJIMA, Yumiko SAGA, Jun KANNO, Ikuo HORII and Tohru INOUE

Paper:

COMBINATION OF FIXATION USING PLP FIXATIVE AND EMBEDDING IN PARAFFIN BY THE AMeX METHOD IS USEFUL FOR HISTOCHEMICAL STUDIES IN ASSESSMENT OF IMMUNOTOXICITY.:

Author:

Masami SUZUKI, Kiyoka KATSUYAMA, Kenji ADACHI, Yumie OGAWA, Keigo YOROZU, Eteuko FUJII, Yasuyuki MISAWA and Tetsuro SUGIMOTO

Paper:

IN VITRO CYTOTOXICITY ASSAY TO SCREEN COMPOUNDS FOR APOPTOSIS-INDUCING POTENTIAL ON LYMPHOCYTES AND NEUTROPHILS.:

Author:

Kazuyuki NAGAMI, Yasunaga KAWASHIMA, Hiroshi KUNO, Masayuki KEMI and Hiroyoshi MATSUMOTO

Paper:

LOCAL LYMPH NODE ASSAY WITH NON-RADIOISOTOPE ALTERNATIVE ENDPOINTS.:

Author:

Akiko SUDA, Masahiro YAMASHITA, Mitsuyuki TABEI, Kazuhiko TAGUCHI, Hans-Werner Vohr, Naohisa TSUTSUI, Ritsuyoshi SUZUKI, Katsuaki KIKUCHI, Keisuke SAKAGUCHI, Kouki MOCHIZUKI and Kazuichi NAKAMURA

8th, 2002

Paper:

DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLYADMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL).:

Author:

NITROSAMINE Toru TAMURA, Kunitoshi MITSUMORI, Horoshi ONODERA, Nariaki FUJIMOTO, Kazuo YASUHARA, Kiyoshi TAKEGAWA, Hisayoshi TAKAGI and Masao HIROSE

Paper:

JUSTIFICATION OF MEASUREMENT OF EIGHT CONGENERS LEVELS INSTEAD OF TWENTY CONGENERS OF DIOXINSZ FOR MASS SCREENING OF HUMAN EXPOSURE.:

Author:

Kimiyoshi KITAMURA, Kazuyuki YOSHIKAWA, Masahiko IWAMA and Minako NAGAO

Paper:

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ??(PPAR??) AGONIST,WY-14,643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES. :

Author:

Takako HAMANO, Kiyoshi KOBAYASHI, Tetsuya SAKAIRI, Masao HAYASHI and Mamoru MUTAI

Paper:

COLLABORATIVE STUDY ON RAT SPERM MOTION ANALYSIS USING CELLSOFT SERIES 4000 SEMEN ANALYZER.:

Author:

Yoshiki BAN, Masato NAYA, Tatsuya NISHIMURA, Masako KANETO, Kurajiro KISHI, Tadahiro INOUE, Hiroshi YOSHIZAKI and Yojiro OOSHIMA

Paper:

OVERVIEW OF STUDIES ON RAT SPERM MOTION ANALYSIS USING A HAMILTON-THORME SPERM ANALYZER.--COLLABORATIVE　WORKING STUDY--.:

Author:

Masashi KATO, Katsuhiro FUKUNISHI, Sunao IKEGAWA, Hashihiro HIGUCHI, Masako SATO, Masao HOROMOTO and Shin ITO

7th, 2001

Paper:

Sex-related effect of hemin on cytochrome P450 and drug-metabolizing enzymes in rat liver.:

Author:

Yasuna KOBAYASHI, Naomi OHSHIRO, Michiya SUZUKI, Tadanori SASAKI, Shogo TOKUYAMA, Takemi YOSHIDA and Toshinori YAMAMOTO

Paper:

Elevation of steroid 5 reductase mRNA levels in rat cerebellum by toluene inhalation : Possible relation to GFAP expression.:

Author:

Takako GOTOHDA, Aki KUWADA, Kyoji MORITA, Shin-ichi KUBO and Itsuo TOKUNAGA

6th, 2000

Paper:

Characterization of epididymal sperm motion and its correlation with stages of target cells in rats given chlorohydrin, cyclophosphamide or nitrazepam.:

Author:

Masako KANETO, Susumu KANAMORI, Katsumi HARA and Kurajiro KISHI

Paper:

Induction of unscheduled DNA synthesis in hairless mouse epidermis by skin carcinogens.:

Author:

Masaaki MORI, Hiroshi KOBAYASHI, Chiyomi SUGIYAMA, Yoshiko KATSUMURA and Chie FURIHATA

5th, 1999

Paper:

Induction of leyding cell tumors by lacidipine via up-regulation of the LHRH receptor on leyding cells in rats.:

Author:

Yoshimasa HAMADA and Yoshihiro FUTAMURA

Paper:

Methylmercuty-induced microtubule depolymerization leads to inhibition of tubulin synthesis.:

Author:

Kyoko MIURA, Yuka KOBAYASHI, Haruka TOYODA and Nobumasa IMURA

4th, 1998

Paper:

Effect of hyperprolactinemia induced by neuroleptic agent,timiperone, on porphyrin content of mouse Harderian gland.:

Author:

Tetsuyo KAJIMURA, Hiroshi SATOH and Mamoru NOMURA

Paper:

A flow cytometric analysis of cytotoxic effects of nitrobenzene on rat sperm atogenesis. :

Author:

Shigeru IIDA, Hirofumi MISAKA and Masato NAYA

3rd, 1997

Paper:

Auditory brainstem response(ABR) and effects of furosemide on ABR in conscious F344 rats.:

Author:

Harushige OZAKI, Kazuyuki KURATA, Akira HORINOUCHI and Takao ANDO

2nd, 1996

Paper:

Effects of all-trans-retinoic acid on limb development in the genetic polydactyly mouse.:

Author:

Minoru TAMAGAWA, Jiro MORITA and Ichiro NARUSE

Paper:

Effects of medroxyprogesterone acetate and estradiol on interleukin-6 production from osteoblasts and bone marrow macrophages of Wistar rats of different ages.:

Author:

Yoshihiro FUTAMURA

1st, 1995

Paper:

Occurrence of autoantibody to protein disulfide isomerase in rats with xenobiotic-induced hepatitis.:

Author:

Sekio NAGAYAMA, Tsuyoshi YOKOI, Yasuro KAWAGUCHI and Tetsuya KAMATAKI

Paper:

Tacrolimus(FK506)-induced nephrotoxicity in spontaneous hypertensive rats.:

Author:

Takashi MITAMURA, Atsushi YAMADA, Hisao ISHIDA, Shiro FUJIHIRA, Kaname OHARA, Hideyo NOGUCHI and Yasuhiro MINE